师资
陈根强,广东省杰出青年基金获得者,加入南方科技大学以来,基于“做实用的化学”的基本理念,在Nat. Chem. (1篇)、Nat. Commun. (2篇)、Sci. Adv. (1篇)、J. Am. Chem. Soc. (3篇)、Angew. Chem. (4篇)、CCS. Chem. (1篇)、Chem. Catal. (1篇) 等国际知名期刊以第一作者或(共同)通讯作者身份发表论文50余篇,申请专利20余项。研究成果1次被国家自然科学基金官方网站亮点介绍 (https://www.nsfc.gov.cn/publish/portal0/tab434/info81246.htm), 4次被Synfacts亮点评述 (Synfacts 2023, 19, 0273; Synfacts 2022, 18, 1329; Synfacts 2020, 16, 1111. Synfacts 2018, 14, 1050),3次被Org. Chem. Highlights进行亮点介绍。2023年入选Org. Chem. Front.新锐科学家。主要研究领域是手性配体的设计合成和在不对称催化中的应用。基于自主开发的新型氧杂螺环二酚O-SPINOL骨架,合成了一系列手性膦配体,其中双膦配体O-SDP已经实现公斤级规模制备,被成功应用于重大药物沙库必曲的不对称合成中,该研究成果已经获得200万元的专利授权费用,目前利用该技术已经生产沙库必曲关键中间体20吨,产值将近4000万。基于氧杂螺环二酚骨架的双亚磷酸酯配体O-SDPhite在混合碳四的异构化氢甲酰化反应中表现出超高的反应活性和选择性,远远超过了目前商业化的Biphephos配体,具有重要的应用价值,该项成果正在进行产业转化。以烯炔环异构化反应为关键步骤实现了前列腺素类药物分子的高效不对称全合成,这是合成前列腺素步骤最短、效率最高的合成路线,国家自然科学基金官方网站以“我国学者在前列腺素合成领域取得进展”为题对该项研究工作进行了亮点介绍,化学通报也对该项工作进行了亮点介绍 (Science China 2021, 66, 3645)。此外,还担任国际知名期刊Nat. Chem.、Nat. Commun.、ACS Catal.、Chem. Sci.、Chem. Commun.等国际知名期刊的评审专家。
教育背景:
2010.09—2015.06 中国科学院上海有机化学研究所 化学 博士
2006.09—2010.06 郑州大学 化学 学士
工作经历:
2021.06—今 南方科技大学 研究副教授
2018.07—2021.05 南方科技大学 研究助理教授
荣誉及奖励:
2021 深圳市自然科学一等奖
2021 深圳市高层次人才引进后备级人才
研究方向:
有机合成,手性配体,不对称催化,不对称氢化等。主要从事新型手性配体的设计合成,以及这些配体在不对称催化领域的应用。
学术成果:
[1] Zong, Y.; Zhang, R.; Ma, B.-D.; Peng, J.; Wu, C.; Zou, X.; Qian, Y.; Chen, G.-Q.*; Zhang, X.*, Robust, scalable, and highly selective spirocyclic catalysts for industrial hydroformylation and isomerization-hydroformylation. Sci. Adv. 2024, 10, eado9607.
[2] Xu, L.; Yang, T.; Sun, H.; Zeng, J.; Mu, S.; Zhang, X.; Chen, G.-Q.*, Rhodium-Catalyzed Asymmetric Hydrogenation and Transfer Hydrogenation of 1,3-Dipolar Nitrones. Angew. Chem., Int. Ed. 2024, 63, e202319662.
[3] Du, X.; Zhang, Y.; Yang, T.*; Xiao, Y.; He, J.; Chung, L. W.; Chen, G.-Q.*; Zhang, X.*, A versatile cobalt catalyst for highly enantioselective hydrogenation of carbonyl compounds. Chem Catal. 2024, 4, 100999.
[4] Wang, F.; Zhang, Z.; Chen, Y.; Ratovelomanana-Vidal, V.; Yu, P.*; Chen, G.-Q.*; Zhang, X.*, Stereodivergent Synthesis of Chiral Succinimides via Rh-Catalyzed Asymmetric Transfer Hydrogenation. Nat. Commun. 2022, 13, 7794.
[5] Wang, F.; Chen, Y.; Yu, P.8; Chen, G.-Q.*; Zhang, X., Asymmetric Hydrogenation of Oximes Synergistically Assisted by Lewis and Bronsted Acids. J. Am. Chem. Soc. 2022, 144, 17763-17768.
[6] Lin, B.; Yang, T.; Zhang, D.; Zhou, Y.; Wu, L.; Qiu, J.; Chen, G.-Q.*; Che, C.-M.*; Zhang, X.*, Gold-Catalyzed Desymmetric Lactonization of Alkynylmalonic Acids Enabled by Chiral Bifunctional P,N ligands. Angew. Chem., Int. Ed. 2022, 61, e202201739.
[7] Zhang, F.; Zeng, J.; Gao, M.; Wang, L.; Chen, G.-Q.*; Lu, Y.; Zhang, X.*, Concise, scalable and enantioselective total synthesis of prostaglandins. Nat. Chem. 2021, 13, 692-697.
[8] Wang, F.; Yang, T.; Wu, T.; Zheng, L.-S.; Yin, C.; Shi, Y.; Ye, X.-Y.; Chen, G.-Q.*; Zhang, X.*, Asymmetric Transfer Hydrogenation of α-Substituted-β-Keto Carbonitriles via Dynamic Kinetic Resolution. J. Am. Chem. Soc. 2021, 143, 2477-2483.
[9] Du, X.; Xiao, Y.; Yang, Y.; Duan, Y.-N.; Li, F.; Hu, Q.; Chung, L. W.; Chen, G.-Q.*; Zhang, X.*, Enantioselective Hydrogenation of tetra-Substituted alpha,beta-Unsaturated Carboxylic Acids Enabled by Cobalt(II) Catalysis: Scope and Mechanistic Insights. Angew. Chem., Int. Ed. 2021, 60, 11384-11390.
[10] Du, X.; Xiao, Y.; Huang, J.-M.; Zhang, Y.; Duan, Y.-N.; Wang, H.; Shi, C.; Chen, G.-Q.*; Zhang, X.*, Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids. Nat. Commun. 2020, 11, 3239.
[11] Chen, G.-Q.*; Huang, J.-M.; Lin, B.-J.; Shi, C.; Zhao, L.-Y.; Ma, B.-D.; Ding, X.-B.; Yin, Q.; Zhang, X.*, Highly Enantioselective Hydrogenation of tetra- and tri-Substituted Unsaturated Carboxylic Acids with oxa-Spiro Diphosphine Ligands. CCS Chem. 2020, 2, 468-477.
[12] Chen, G.-Q.; Lin, B.-J.; Huang, J.-M.; Zhao, L.-Y.; Chen, Q.-S.; Jia, S.-P.; Yin, Q.; Zhang, X., Design and Synthesis of Chiral oxa-Spirocyclic Ligands for Ir-Catalyzed Direct Asymmetric Reduction of Bringmann's Lactones with Molecular H2. J. Am. Chem. Soc. 2018, 140, 8064-8068.
[13] Chen, G.-Q.; Zhang, X.-N.; Wei, Y.; Tang, X.-Y.; Shi, M., Catalyst-dependent divergent synthesis of pyrroles from 3-alkynyl imine derivatives: A noncarbonylative and carbonylative approach. Angew. Chem., Int. Ed. 2014, 53, 8492-8497.