师资
个人简介
南方科技大学讲席教授、医学院副院长，乌克兰工程院外籍院士，国际华人骨研学会现任主席，广东省细胞微环境与疾病研究重点实验室主任, 美国骨矿研究学会(ASBMR)会士, 连续荣登爱思唯尔中国高被引学者 （生物学)和全球前2%顶尖科学家榜单。研究骨骼发育和骨骼疾病 （骨质疏松、骨关节炎等）的相关分子基础。北京大学医学部博士；美国密歇根大学博士后；美国匹茨堡大学医学院助理教授、副教授；美国拉什大学教授、冠名讲席教授、生物化学系的研究主任；历任南方科技大学生物系系主任、致诚书院院长。主持国自然重大、重点等项目。发表SCI文章183篇, 引用约18500次，总影响因子约1875, H指数68。实验室成果在国际骨科研究大会获奖10余次。担任JOT副主编, 担任JBMR及 JBC等国际学术刊物编委，担任67个国际杂志的审稿人。北京大学医学部（原北京医科大学）100周年校庆，优秀校友。
研究领域
（1）研究调节骨骼发育及稳态的分子机制；
（2）研究骨质疏松症，骨性关节炎及脊柱退行性变等骨骼疾病的分子基础；
（3）研究骨机械应力信号传导机制；
（4）代谢性疾病的发病机制研究。
教育背景
1991-1994：北京大学医学部生物化学和分子生物学系，博士学位
1985-1988：北京大学医学部生物化学和分子生物学系，硕士学位
1979-1984：南昌大学医学院医疗系，医疗专业，医学学士学位
工作经历
2020- 南方科技大学教授, 医学院副院长
2019-2020 南方科技大学致诚书院院长
2017- 南方科技大学实验动物中心主任
2015-2018 南方科技大学生物系系主任
2013-2019 南方科技大学生物系教授
2012-2017 美国拉什大学医学中心副教授，正教授、讲席教授(Falk Chair Professor)、生物化学系科研主任
2005-2011 美国匹兹堡大学医学院助理教授、终身副教授
1994-2005 美国密歇根大学医学院/牙学院博士后、讲师、研究助理教授
1988-1991 北京大学医学部， 讲师
获奖情况及荣誉
2023 国际华人骨研学会主席 (International Chinese Musculoskeletal Research Society (ICMRS), president); https://icmrs.net/leadership
2022 南方科技大学优秀研究生导师奖
2022 乌克兰工程院外籍院士
2022, 2023 全球前2%顶尖科学家 (World's Top 2% Scientists by Stanford University)
2021, 2022 爱思唯尔 (Elsevier)中国高被引学者 （生物学）(Most Cited Chinese Researchers, Biology)
2020 南方科技大学年度教授奖
2019 国际骨科研究联合学会 (FIOR)，会士
2019 美国骨与矿物质研究学会 (ASBMR), 会士
2012 北京大学医学部(原北京医科大学) 100周年校庆，优秀校友
杂志编委、副主编
2023- Journal of Orthopaedic Translation (JOT), associate editor
2009-2015 Journal of Bone and Mineral Research (JBMR), editorial board member
2013-2022 Journal of Biological Chemistry (JBC), editorial board member
代表文章
From total 200 publications
1. Walke W, Xiao G, and Goldman D. A dual function activity-dependent, muscle-specific enhancer from rat nicotinic acetylcholine receptor d-subunit gene. J Neurobiol. 1996; 31(3): 359-369.
2. Walke W, Xiao G, and Goldman D. Identification and characterization of a 47 base pair activity-dependent enhancer of the rat nicotinic acetylcholine receptor d-subunit promoter. J Neurosci. 1996; 16(11): 3641-3651.
3. Xiao G, Cui Y, Ducy P, Karsenty G, and Franceschi RT. Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol. 1997; 11:1103-1113.
4. Xiao G, Wang D, Benson MD, Karsenty G, and Franceschi RT. Role of the a2 integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem. 1998; 273, 32988-32994.
5. Frendo JL, Xiao G, Fuches S, Franceschi RT, Karsentry G, and Ducy P. Functional hierarchy between two OSE2 elements in the control of osteocalcin expression in vivo. J Biol Chem. 1998; 273, 30509-30516.
6. Wang D, Christensen, K, Chawla, K, Xiao G, Krebsbach P. and Franceschi, RT. Isolation and characterization of MC3T3-E1 murine preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. J Bone Miner Res. 1999; 14:893-903.
7. Benson MD, Aubin JE, Xiao G, Thomas PE, and Franceschi RT. Cloning of a 2.5 kb murine bone sialoprotein promoter fragment and functional analysis of putative Cbf/runt binding sites. J Bone Miner Res. 1999; 14:396-405.
8. Xiao G, Jiang D, Thomas PE, Benson MD, Guan KL, Karsenty G, and Franceschi RT. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Osf2/Cbfa1. J Biol Chem. 2000; 275, 4453-4459.
9. Benson MD, Bargeon JL, Xiao G, Thomas PE, Ahn Kim, Yingqi Cui, and Franceschi RT. Identification of a homeodomain binding element in the bone sialoprotein gene promoter which is required for its osteoblast-selective expression. J Biol Chem. 2000; 275: 13907-13917.
10. Franceschi RT. Xiao G, Thomas PE, Jiang D, and Benson MD. Extracellular matrix regulation of osteoblast-specific gene expression: role of the a2b1 integrin and Osf2/Cbfa1. Chemistry and Biology of Mineralized Tissues: Connect Tissue Res. 2000;41 Suppl 1:249-254.
11. Ma PX, Zhang R, Xiao G, and Franceschi RT. Engineering new bone tissue in vitro on highly pore poly(-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res. 2001; 54:284-293.
12. Xiao G, Jiang D, Gopalakrishnan R, and Franceschi RT. FGF-2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem. 2002; 277:36181-36187.
13. Zhao M, Xiao G, Berry J, Franceschi RT, Reddi A, and Somerman MJ. Bone Morphogenetic Protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J Bone Miner Res. 2002; 17:1441-1451.
14. Xiao G, Gopalakrishnan R, Jiang D, Reith E, Benson MD, and Franceschi RT. BMP, extracellular matrix, and MAP kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res. 2002; 17:101-110.
15. Franceschi RT and Xiao G. Regulation of osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways. J Cell Biochem. 2003; 88:446-454.
16. Franceschi RT. Xiao G, Jiang D, Gopalakrishnan R, Yang S and Reith E. Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation: Connect Tissue Res. 2003;44 Suppl 1:109-16.
17. Chen C, Koh AJ, Datta NS, Zhang J, Even ET, Xiao G, Franceschi RT, D'Silva NJ, and McCauley LK. Impact of mitogen-activated protein kinase (MAPK) pathway on parathyroid hormone related protein actions in osteoblasts. J Biol Chem. 2004; 279, 29121-29129.
18. Jiang D, Franceschi RT, Boules H, and Xiao G*. Parathyroid Hormone Induction of the Osteocalcin Gene:requirement for an osteoblast-specific element 1 sequence in the promoter and involvement of multiple signaling pathways. J Biol Chem. 2004; 279:5329-5337.
19. Xiao G*, Jiang D, Ge C, Zhao Z, Yumei Lai, Boules H, Phimphilai M, Yang X, Karsenty G, and Boules H, and Franceschi RT. Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem. 2005; 280:30689-30696.
20. Roca H, Phimphilai M, Gopalakrishnan R, Xiao G, and Franceschi RT. Cooprative interactions between RUNX2 and homeodomain protein binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. J Biol Chem. 2005; 280:30845-30855.
21. Zhao Z, Zhao M, Xiao G, and Franceschi RT. Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo. Mol Ther. 2005; 12(2):247-53.
22. Lu, Y, Cai Z, Galson DL, Xiao G, Liu, Y, George DE, Melhem MF, Yao Z, Zhang J. Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion. Prostate. 2006; 66(12): 1311-8.
23. Franceschi RT, Xiao G. Osteoblasts: Staying the course. Meeting report from the 29th Annual Meeting of the American Society for Bone and Mineral Research. BoneKEy-Osteovision 2006; 4 (12), 327-332.
24. Zhu J, Jia X, Xiao G, Kang Y, Partridge, NC, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors in osteoblasts: implications in osteolytic bone metastases. J Biol Chem.2007; 282(37): 26656-64.
25. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Ann N Y Acad Sci. 2007; 1116:196-207.
26. Lu Y, Xiao G, Galson DL, Nishio Y, Mizokami A, Keller E, Yao Z, and Zhang J. PTHrP-induced production of monocyte chemoattractant protein-1 (MCP-1) by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation in vitro: a novel role in prostate cancer bone metastasis. Int J Cancer. 2007; 121(4): 724-733.
27. Lu Y, Cai Z, Xiao G, Liu Y, Keller E, Yao Z, and Zhang J. CCR2 expression correlates with prostate cancer progression. J Cell Biochem. 2007; 101(3): 676-85.
28. Lu Y, Cai Z, Xiao G, Yao Z, Anderson JL, Roodman DG, and Zhang J. Prostate cancer cells induce osteoclastogenesis and bone resorption through RANKL-independent interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) production. Cancer Res. 2007; 67(8): 3646-53.
29. Ge C, Xiao G, Jiang D, and Franceschi RT. Critical role of extracellular signal-regulated kinase/MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol. 2007; 176(5): 709-818. PMCID: PMC2064027.
30. Feng, R, Anderson G, Xiao G, Elliot G, Leoni L, Lapara MY, Roodman GD, and Lentzsch S. SDX-308, a non-steroidal anti-inflammatory agent, inhibits NF-kB activity resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth. Blood. 2007; 109(3): 2130-2138.
31. Yu S, Franceschi RT, Luo M, Zhang X, Jiang D, Lai Y, Jiang Y, Zhang J, Xiao G. Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression. Endocrinology. 2008; 149(4): 1960-8. PMCID: PMC2276723.
32. Singha UK, Jiang Y. Yu S, Luo M, Lu Y, Zhang J, Xiao G. Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells. J Cell Biochem. 2008 Feb 1;103(2):434-46. doi: 10.1002/jcb.21411.PMID: 17516572。
33. Chen D, Xiao G, Zhang M, Xing L, and Jonason JH. Post-translational regulation of Runx2 in bone cells. J Dent Res. 2008; 88(8): 693-703.
34. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Cells Tissues Organs. 2009;189(1-4):144-152.
35. Yu S, Jiang Y, Galson DL, Luo M, Lai Y, Lu Y, Ouyang HJ, Zhang J, Xiao G. General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. J Biol Chem. 2008; 283(9): 5542-53. PMCID: PMC2736298.
36. Zhang X, Yu S, Galson, DL, Luo M, Fan J, Zhang J, Guan Y, Xiao G. Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts. J Cell Biochem. 2008; 105(3): 885-95. PMCID: PMC2704124.
37. Liu Y, Yuan Y, Li Y, Zhang J, Xiao G, Vodovotz Y, Billiar TR, Wilson M, Fan J. Interacting neuro-endocrine, innate, and acquired immune pathways regulate neutrophil from bone marrow following hemorrhage shock. J Immnol. 2009;182(1):572-580. PMCID: PMC2610356.
38. Cai, Z, Chen Q, Chen J, Lu Y, Xiao G, Wu Z, Zhou Q, Zhang J. Monocyte chemotactic protein-1 promotes lung cancer-induced bone resorptive lesion in vivo. Neoplasia. 2009;11(3):228-36. PMCID: PMC2647725.
39. Yu S, Franceschi RT, Luo M, Fan J, Jiang D, Cao H, Lai Y, Zhang J, Patrene K, Hankenson KD, Roodman GD, Xiao G. Critical role of activating transcription factor 4 in the anabolic actions of PTH in bone. PLoS One. 2009, Oct 23;4(10):e7583. PMCID: PMC2762317. (This paper was listed as the "Not to be Missed" paper in the November (2009) issue of the IBMS BoneKEy. BoneKEy is published by the International Bone & Mineral Society).
40. Ge C, Xiao G (co-first author), Jiang D, Yang Q, Hatch NE, and Franceschi RT. Identification and functional characterization of extracellular-regulated kinase/MAPK phosphorylation sites in the Runx2 transcription factor. J Biol Chem. 2009; 284(47):32533-43. PMCID: PMC2781667.
41. Li Y, Xiang M, Yuan Y, Xiao G, Zhang J, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. HMGB1 upregulation of TLR2 augments hemorrhagic shock-Induced ICAM-1 expression in lung endothelial cells. Am J Physiol Regul Integr Comp Physiol. 2009; 297(6):R1670-80, PMCID: PMC2803625.
42. Cao H, Yu S, Yao Z, Galson DL, Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, Lai Y, Zhu, Y, Kurihara N, Patrene K, Roodman GD, Xiao G. Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest. 2010 Aug 2;120(8):2755-66. PMCID: PMC2912190.
43. Wu, Z, Jiao P, Huang, X, Feng Y, Feng B, Yang S, Hwang P, Du J, Hall RK, Xiao G, Xu H. MAP kinase phosphatase 3 regulates glucose homeostasis through dephosphorylation of FOXO1 in mice. J Clin Invest. 2010 Nov 1;120(11):3901-11. PMCID: PMC2964981.
44. Xiang M, Yin L, Li Y, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activates lung endothelial NAD(P)H oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol. 2011 Mar;44(3):333-40. PMCID: PMC3095934.
45. Yang S, Xu H, Yu S, Cao H, Jie Fan, Ge C, Fransceschi RT, Dong HH, Xiao G. Foxo1 mediates IGF1/Insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. J Biol Chem. 2011; 286(21):19149-58. PMCID: PMC3099728.
46. Xiang M, Shi X, Li Y, Xu J, Yin L, Xiao G, Scott MJ, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. J Immnol. 2011; 187(9) :4809-17, PMCID: PMC3197874.
47. Danciu TH, Li Y, Koh A, Xiao G, McCauley LK, Franceschi RT. The basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts. J Cell Biochem. 2011;113(1):70-9. PMCID: PMC3414260.
48. D'Souza S, Del Prete D, Jin S, Sun Q, Huston AJ, Kostov FE, Sammut B, Hong CS, Anderson JL, Patrene KD, Yu S, Velu CS, Xiao G, Grimes HL, Roodman GD, Galson DL. Gfi-1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease. Blood. 2011;118(26):6871-80. PMCID: PMC3245209.
49. Tang W, Yang F, Li Y, de Crombrugghe B, Jiao H, Xiao G, and Zhang C. Transcriptional regulation of vascular endothelial growth factor (VEGF) by osteoblast-specific transcription factor osterix (Osx) in osteoblasts. J Biol Chem. 2012 Jan 13;287(3):1671-8. PMCID: PMC3265850.
50. Xiang M, Yuan Y, Fan L, Li Y, Li A, Yin L, Scott MJ, Xiao G, Billiar TR, Wilson MA, Fan J. Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells From Bone Marrow After Hemorrhagic Shock. Shock. 2012 May;37(5):518-523. PMCID: PMC3328610.
51. Li X, Ellman MB, Kroin JS, Chen D, Yan D, Mikecz K, Kc R, Xiao G, Stein GS, Kim SG, Cole B, van Wijnen AJ, Im HJ. Species-specific biological effects of FGF-2 in articular cartilage: Implication for distinct roles within the FGF receptor family. J Cell Biochem. 2012 Jul;113(7):2532-42. PMCID: PMC3349778.
52. Xiao G*, Cheng H, Cao H, Chen K, Tu Y, Yu S, Jiao H, Yang S, Im HJ, Chen D, Chen J, Wu C*. Critical role of Filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem. 2012 June 15;287(25):21450-60. PMCID: PMC3375566.
53. Ellman MB, Kim JS, An HS, Chen D, Ranjan KC, An J, Dittakavi T, van Wijnen AJ, Cs-Szabo G, Li X, Xiao G, An S, Kim SG, Im HJ. Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disc homeostasis: in vitro, ex vivo studies. Gene. 2012 Sep 1;505(2):283-90, PMCID: PMC3518428.
54. Yan D, Chen D, Xiao G, van Wijnen A, Im HJ. Bovine lactoferricin, an antimicrobial peptide, is anti-inflammatory and anti-catabolic in human articular cartilage and synovium. J Cell Physiol. 2013 Feb;228(2):447-56, PMCID: PMC3463726.
55. Meng M, Jin H, Wang B, Yukata K, Sheu TJ, Ke QH, Tong P, Im HJ, Xiao G, Chen D. Chondrocyte BMP-2 Signaling Plays a Critical Role in Bone Fracture Healing. Gene. 512 (2013) 211–218. PMCID: PMC3531824.
56. Yu S, Sharma R, Nie D, Jiao H, Lai Y, Fan J, Im HJ, Chen D, Wang Q, Xiao G. ADAR1 is required for osteoblast differentiation and bone homeostasis. Gene. 513 (2013) 101–110. PMCID: PMC3514579.
57. Yu S, Zhu K, Lai Y, Zhao Z, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes β-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells. Int J Biol Sci. 2013; 9(3):256-266. PMCID: PMC3596711.
58. Xu P, Wen Z, Shi X, Li Y, Fan L, Xiang M, Li A, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J. Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through impaired pyrin induction. J Immunol. 2013 May 15;190(10):5247-55. PMCID: PMC3646900.
59. Kim JS, Ellman MB, Yan D, An HS, Kc R, Li X, Chen D, Xiao G, Cs-Zabo G, Hoskin DW, Buechter DD, van Wijnen AJ, Im HJ. Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc. J Cell Physiol. 2013 Sep;228(9):1884-96. PMCID: PMC3703102.
60. Ellman MB, Kim J, An HS, Chen D, Kc R, Li X, Xiao G, Yan D, Suh J, van Wijnen A, Wang J, Kim S, Im H. Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells. Gene. 2013 Jul 25;524(2):282-91. PMCID: PMC3679319.
61. Liu Z, Jiang Y, Li Y, Wang J, Fan L, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J. TLR4 signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation. J Immunol. 2013 Jul 15;191(2):857-64. PMCID: PMC3702632.
62. Zheng L, Zhu K, Jiao H, Zhao Z, Zhang L, Liu M, Chen D, Yao Z, Xiao G. PTHrP expression in human MDA-MB-231 breast cancer cells is critical for tumor growth and survival and osteoblast inhibition. Int J Biol Sci. 2013 Aug 21;9(8):830-41. PMCID: PMC3753447.
63. Xiao G*, Zhang T, Yu S, Lee A, Calabuig-Navarro V, Ringquist S, Dong HH*. ATF4 deficiency protects against high fructose-induced hypertriglyceridemia in mice. J Biol Chem. 2013 Aug 30;288(35):25350-61. PMCID: PMC3757199.
64. Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res.2013;28: 1870–1884. PMID: 23649506. This is an EDITOR'S CHOICE paper of September 2013 JBMR issue and highlighted with a Commentary paper ( Schipani et al. J Bone Miner Res. 2013;28:1866-1869. DOI: 10.1002/jbmr.2045).
65. Cao H, Zhu K, Qiu L, Li S, Niu H, Hao M, Yang S, Zhao Z, Lai Y, Anderson JL, Fan J, Im HJ, Chen D, Roodman GD, Xiao G. Critical role of AKT in myeloma-induced osteoclast formation and osteolysis. J Biol Chem. 2013 Oct 18;288(42):30399-410. PMCID: PMC3798504.
66. Yan D, Kc R, Chen D, Xiao G, Im H. Bovine lactoferricin-induced anti-inflammation is, in part, via upregulation of IL-11 by secondary activation of STAT3 in human articular cartilage. J Biol Chem. 2013 Nov 1;288(44):31655-69. PMID: 24036113.
67. Wang B, Jin H, Zhu M, Li J, Zhao L, Zhang Y, Tang D, Xiao G, Xing L, Boyce BF, Chen D Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of Rankl/Opg expression and osteoclast differentiation. Arthritis Rheumatol. 2014 Jan;66(1):107-20. doi: 10.1002/art.38195. PMID: 244312822.
68. Li TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G, Konttinen YT, Chen D, O'Keefe RJ. BMP-2 regulates chondrocyte differentiation through modulation of COX-2 and ATF4. Osteoarthritis Cartilage. 2014 Mar;22(3):481-9. PMID: 24418675.
69. Li S, Shu B, Zhang Y, Li J, Guo J, Wang Y, Ren F, Xiao G, Chang Z, Chen D. CHIP regulates osteoclast formation through promoting TRAF6 protein degradation. Arthritis Rheumatol. 2014 Jul;66(7):1854-63. doi: 10.1002/art.38521. PMID: 24578159.
70. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, Li Y, Scott MJ, Xiao G, Li S, Fan L, Billiar TR, Wilson MA, Fan J. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014 Aug;21(8):1229-39. PMID: 24769733. PMCID: PMC4085529.
71. Qu H, Tu Y, Guan JL, Xiao G, Wu C. Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit. J Biol Chem. 2014 Nov 7;289(45):31001-13. PMID: 2523719.
72. Wen Z, Fan L, Li Y, Zou Z, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Shi X, Fan J. Neutrophils counteract autophagy-mediated anti-inflammatory mechanisms in alveolar macrophage: role in posthemorrhagic shock acute lung inflammation. J Immunol. 2014 Nov 1;193(9):4623-33. PMID: 25267975.
73. Niu NK, Wang ZL, Pan ST, Ding HQ, Au GHT, He ZX, Zhou ZW, Xiao G, Yang YX, Zhang X, Yang T, Chen XW, Qiu JX, Zhou SF. Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway. Drug Des Devel Ther. 2015 Mar 12;9:1555-84. PMID: 25792811.
74. Zhu K, Yi J, Xiao Y, Lai Y, Song P, Zheng W, Jiao H, Fan J, Wu C, Chen D, Zhou J, Xiao G. Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy. J Biol Chem. 2015 Mar 27;290(13):8081-94. doi: 10.1074/jbc.M114.603985. Epub 2015 Feb 3. PMID: 25648889.
75. Wu C, Jiao H, Lai Y, Zheng W, Chen K, Deng W, Song P, Zhu K, Cao H, Galson DL, Fan J, Im HJ, Liu Y, Chen J, Chen D, Xiao G. Kindlin-2 controls TGF-β signaling and Sox9 expression to regulate chondrogenesis. Nat Commun. 2015 Jul 7;6:7531. doi: 10.1038/ncomms8531. PMID: 26151572.
76. Kim JS, Ahmadinia K, Li X, Hamilton JL, Andrews S, Haralampus CA, Xiao G, Sohn HM, You JW, Seo YS, Stein GS, Van Wijnen AJ, Kim SG, Im HJ. Development of an experimental animal model for lower back pain by percutaneous injury-induced lumbar facet joint osteoarthritis. J Cell Physiol. 2015 Nov;230(11):2837-47. doi: 10.1002/jcp.25015. PMID: 25858171.
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151. Yao Q, Gong W, Wu X, Gan D, Tao C, Lin S, Qu M, Ouyang Z, Chen M, Hu X, Xiao G. Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4CreERT2 versus AggrecanCreERT2 transgene in mice. J Orthop Translat. 2023 May 31;41:12-19. doi: 10.1016/j.jot.2023.05.005. eCollection 2023 Jul. MID:37292436, PMCID: PMC10244901, DOI: 10.1016/j.jot.2023.05.005.
152. Qin L, Chen Z, Yang D, He T, Xu Z, Zhang P, Yi W, Xiao G. Osteocyte b3 integrin promotes bone mass accrual and force-induced bone formation in adult mice. J Orthop Translat. 2023 Jun 7;40:58-71. doi: 10.1016/j.jot.2023.05.001. eCollection 2023 May. PMID: 37457310
153. Xie X, Zhang W, Xiao M, Qiu J, Wang H, Qiu Z, Zhang S, Mao L, Wei T, Li Y, Hu S, Pan Y, Chen Z, Li L, Lu Y, Gong Y, Yang J, Xiao G*, Zhang Y*, Bai X*. TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia. Blood. 2023 Jun 29;141(26):3184-3198. doi: 10.1182/blood.2022018619. PMID: 37001042
154. Gao H, Zhong Y, Lin S, Yan Q, Yao Q, Zou X, Xiao G. Adipoq+ cell population controls bone mass via sclerostin in the bone microenvironment in mice. Signal Transduct Target Ther (STTT). 2023 Jul 10;8(1):265. doi: 10.1038/s41392-023-01461-0. PMID: 37423945. Paper of the Month - January 2024 selected by the BMAS Scientific Board (https://bma-society.org/paper-of-the-month/)
155. Wu X, Chen M, Lin S, Chen S, Gu J, Wu Y, Qu M, Gong W, Yao Q, Li H, Zou X, Chen D, Xiao G. Loss of Pinch Proteins Causes Severe Degenerative Disc Disease-Like Lesions in Mice. Aging Dis. 2023 Oct 1;14(5):1818-1833. doi: 10.14336/AD.2023.0212. PMID: 37196110
156. Chen S, Yang W, Chen M, Liu S, Shao Z, Xiao G. Regulated cell death in musculoskeletal formation, homeostasis, and diseases. Fundamental Research (2023).doi: https://doi.org/10.1016/j.fmre.2023.08.009
157. Lu K, Zhang M, Wei G, Xiao G, Tong L, Chen D. Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability. Elife. 2023 Nov 9;12:e80327. doi: 10.7554/eLife.80327. Online ahead of print. PMID: 37943017
158. Aging Biomarker Consortium, Jinlong Suo, Yibo Gan, Yangli Xie, Shuqin Xu, Jianfang Wang, Di Chen, Lin Chen, Lianfu Deng, Shiqing Feng, Jingdong Jackie Han, Qing Jiang, Guanghua Lei, Peng Liu, Xianghang Luo, Xin Ma, Jing Qu, Chunli Song, Peifu Tang, Tingting Tang, Sijia Wang, Xiaochun Wei, Chengtie Wu, Guozhi Xiao*, Liu Yang, Licheng Zhang, Weiqi Zhang, Zhenlin Zhang, Guang-Hui Liu, Changqing Zhang, Gang Pei, Jian Luo, Rui Yue, Weiguo Zou, A framework of biomarkers for skeletal aging: a consensus statement by the Aging Biomarker Consortium. Life Medicine, 2023; lnad045, https://doi.org/10.1093/lifemedi/lnad045
159. Li J, Liu B, Wu H, Zhang S, Liang Z, Guo S, Jiang H, Song Y, Lei X, Gao Y, Cheng P, Li D, Wang J, Liu Y, Wang D, Zhan N, Xu J, Wang L, Xiao G, Yang L, Pei G. Sensory nerves directly promote osteoclastogenesis by secreting Peptidyl-prolyl cis-trans isomerase D (Cyp40). Bone Res. 2023 Dec 14;11(1):64. doi: 10.1038/s41413-023-00300-w. PMID: 38097598
160. Yi D, Jin H, Lu WW, Zhang C, Xiao G, Tong L, Chen D, Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice. Genes Dis. 2023 Oct 19;11(4):101147. doi: 10.1016/j.gendis.2023.101147. eCollection 2024 Jul.PMID: 38515941
161. Gan D, Jin X, Wang X, Tao C, Yan Q, Jia Q, Huo S, Chen D, Yao Q, Xiao G. Pathological progress and remission strategies of osteoarthritic lesions caused by long-term joint immobilization. Arthritis Res Ther. 2023 Dec 7;25(1):237. doi: 10.1186/s13075-023-03223-3.PMID: 38062473
162. Qin L, Xiao G. Primary astrocytes purification and immortalization. Curr Protoc. 2023 Dec;3(12):e964. doi: 10.1002/cpz1.964. PMID: 38131300
163. He T, Zhou B, Cheng H, Yan Q, Lin S, Ma G, Yao Q, Wu X, Zhong Y, Gan D, Huo S, Jin W, Chen D, Bai X, Cheng T, Cao H, Xiao G. The bone-liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway. Cell Death Differ. 2024 Jan;31(1):90-105. doi: 10.1038/s41418-023-01243-9. Epub 2023 Dec 7.
164. Zhong Y, Zhou L, Wang H, Lin S, Liu T, Kong X, Xiao G*, Gao H*. Kindlin-2 loss in hepatocytes causes liver dysfunction by stimulating oxidative stress and osteopontin-dependent inflammation in mice. J Biol Chem. 2024 Feb;300(2):105601. doi: 10.1016/j.jbc.2023.105601. Epub 2023 Dec 28. PMID: 38159860
165. Liao Z, Umar M, Huang X, Qin L, Xiao G, Chen Y, Tong L, Chen D. Transient receptor potential vanilloid 1: A potential therapeutic target for the treatment of osteoarthritis and rheumatoid arthritis. Cell Prolif. 2024 Mar;57(3):e13569. doi: 10.1111/cpr.13569. Epub 2023 Nov 23. PMID: 37994506
166. Yao Q, He T, Liao J, Liao R, Wu X, Lin L, Xiao G. Noncoding RNAs in the development and disorders of the skeletal system. Biol Res. 2024 Apr 22;57(1):16. doi: 10.1186/s40659-024-00497-y.PMID: 38644509
167. Huo S, Tang X, Chen W, Gan D, Guo H, Yao Q, Liao R, Huang T, Wu J, Yang J, Xiao G*, Han X*. Epigenetic regulations of cellular senescence in osteoporosis. Ageing Res Rev. 2024 Feb 15:102235. doi: 10.1016/j.arr.2024.102235. Online ahead of print.
168. Lin S, Tao C, Yan Q, Gao H, Qin L, Zhong Y, Yao Q, Zhang P, Yang J, Zou X, Xiao G. Pip5k1c expression in osteocytes regulates bone remodeling in mice. J Orthop Translat. 2024 Mar 8;45:36-47. doi: 10.1016/j.jot.2023.10.008. eCollection 2024 Mar. PMID: 38495744
169. Liang W, Wei T, Hu L, Chen M, Tong L, Zhou W, Duan X, Zhao X, Zhou W, Jiang Q, Xiao G, Zou W, Chen D, Zou Z, Bai X. An integrated multi-omics analysis reveals osteokines involved in global regulation. Cell Metab. 2024 Mar 28:S1550-4131(24)00085-8. doi: 10.1016/j.cmet.2024.03.006. Online ahead of print. PMID: 38574738
170. Huang C, Zeng B, Zhou B, Chen G, Zhang Q, Hou W, Xiao G, Duan L, Hong N, Jin W, Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis, Genes Dis. https://doi.org/10.1016/j.gendis.2024.101241.
171. D Zeng, M Umar, Z Zhu, H Pan, WW Lu, G Xiao, Y Chen, L Tong, D Chen. Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signaling. Genes Dis. 2024-02, p.101247, Article 101247 DOI: 10.1016/j.gendis.2024.101247
172. Chen H, Fu X, Wu X, Qiu F, Zhao J, Wang Z, Wang Z, Chen X, Xie D, Huang J, Fan J, Yang X, Song Y, Li J, He D, Xiao G*, Lu A*, Chao Liang X*. Integrative multi-omics approaches for identifying gut microbiota-derived propionate targeting synovial fibroblasts to ameliorate rheumatoid arthritis. Bone Res. 2024 May 23;12(1):31. doi: 10.1038/s41413-024-00336-6. PMID: 38782893
173. Gan D, Tao C, Jin X, Jia Q, Wu X, Yan Q, Zhong Y, Wu L, Huo S, Xiao G. Piezo1 activation accelerates osteoarthritis progression and the targeted therapy effect of artemisinin. J Adv Res. 62 (2024) 105–117. PMID: 37758057
174. Xie J, Liu X, Wu B, Chen B, Song Q, Guan Y, Gong Y, Yang C, Lin J, Huang M, Tan X, Lai R, Lin X, Zhang S, Xie X, Chen X, Zhang C, Yang M, Nong H, Zhao X, Xia L, Zhou W, Xiao G, Jiang Q, Zou W, Chen D, Lu D, Liu J, Bai X. Bone transport induces the release of factors with multi-tissue regenerative potential for diabetic wound healing in rats and patients. Cell Rep Med. 2024 Jun 18;5(6):101588. doi: 10.1016/j.xcrm.2024.101588. Epub 2024 May 22. PMID: 38781961.
175. Chen M, Li F, Qu M, Jin X, He T, He S, Yao Q, Wang L, Chen D, Wu X, Xiao G. Pip5k1g promotes anabolism of nucleus pulposus cells and intervertebral disc homeostasis by activating CaMKII-Ampk pathway in aged mice. Aging Cell. 2024 Jun 5:e14237. doi: 10.1111/acel.14237. Online ahead of print. PMID: 38840443
176. Lu K, Zhang M, Qin H, Shen S, Song H, Jiang H, Zhang C, Xiao G, Tong L, Jiang Q, Chen D. Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma. Acta Pharmaceutica Sinica B (APSB) 2024 Jul;14(7):2977-2991. doi: 10.1016/j.apsb.2024.03.013. Epub 2024 Mar 10. PMID: 39027231
177. Tao C, Lin S, Shi Y, Gong W, Chen M, Li J, Zhang P, Yao Q, Qian D, Ling Z, Xiao G. Loss of Tnfr attenuates age-related intervertebral disc degeneration in mice. JOR Spine. 2024 Oct 8;7(4):e70006. doi: 10.1002/jsp2.70006. eCollection 2024 Dec. PMID: 39391171
178. Yi D., Xie R., Zeng D., Jun Xiao J, Xiao G, Jin H, Tong L, Chen D (2024). Loss of Axin1 in limb mesenchymal cells leads to multiple synostoses syndrome-like phenotype in mice. The Innovation Medicine2(1): 100053. https://doi.org/10.59717/j.xinn-med.2024.100053
Xiao Lab 光荣榜：
Xiaohao Wu, School of Medicine Dean’s Fellowship, Stanford University, $35,000, 2024；
Xiaohao Wu, Stanford Translational and Applied Medicine Pilot Grant, Stanford University, $20,000, 2024.
金小琬，南方科技大学2024年“艺术优秀奖”研究生
金小琬，南方科技大学2024年“优秀毕业研究生”
金小琬，南方科技大学2024年“优秀硕士学位论文”
甘东浩，Postdoc, Yale University, 2024
河泰麟，南方科技大学2024年研究生“十佳毕业生”（博士研究生）候选人
钟一鸣，首批国家自然科学基金青年学生基础研究项目(博士研究生), 30万, 2024
Talin He，The 5th ICMRC Presidential Award; oral presentation; the highest ranking abstract from about 600 abstracts, 2024
Jiaming Yang，The 5th ICMRC Young Investigator Award, 2024
陈明珏，南方科技大学医学院第三届“未来之星”论坛，三等奖, 2023
淘楚，南方科技大学医学系统学术年会，三等奖， 2023
河泰麟，南方科技大学医学系统学术年会，优秀奖，2023
钟一鸣，博士研究生国家奖学金, 2023
Donghao Gan, ASBMR Young Investigator Award, 2023
Talin He，ICMRS Webster Jee Young Investigator Award, oral presentation, 2023
吴晓昊，Postdoc, Stanford University, 2023
吴晓昊，南方科技大学2023年研究生“十佳毕业生” (博士研究生)
吴晓昊，南方科技大学医学院“院长奖”，2023
吴晓昊，2022年“广东省生命健康研究生学术论坛”口头报告一等奖, 2023
Donghao Gan, ICMRS Webster Jee Young Investigator Award, 2023
姚青, 国自然面上基金, 53万，2022
河泰麟，南方科技大学医学院，优秀博士生，2022
陈明珏，南方科技大学医学院，优秀研究生，2022
钟一鸣，南方科技大学医学院“院长奖”，2022
河泰麟，南方科技大学医学院2021度优秀研究生，2022
钟一鸣，南方科技大学校级硕士学位论文，2022
钟一鸣，南方科技大学校级优秀研究生毕业生，2022
钟一鸣，南方科技大学2022年研究生“十佳毕业生”（硕士研究生）
甘东浩，教育部博士后基金, 8万，2022
Mingjue Chen, ICMRS Webster Jee Young Investigator Award, 2022
陈明珏，硕士研究生国家奖学金, 2022
吴晓昊，博士研究生国家奖学金, 2022
陈明珏，南方科技大学医学院第二届“未来之星”论坛，二等奖, 2022
甘东浩，第二届南方科技大学医疗系统学术年会, 二等奖, 2022
林嗣雄，第二届南方科技大学医疗系统学术年会, 三等奖，2022
Lei Qin, ASBMR Young Investigator Award, 2021
曹惠玲, 科技部重大专项, 67万，2021
王依姝，教育部博士后基金, 8万，2021
Xiaohao Wu, ASBMR Felix Bronner Young Investigator Award; the highest ranking abstract, 2021
钟一鸣 南方科技大学生命科学学院第二届“学术之星”论坛优秀奖，2021
Xiaohao Wu, ICMRS Webster Jee Young Investigator Award, 2021
陈明珏，研究生国家奖学金，2021
高焕庆，首届南方科技大学医学系统学术年会，一等奖， 2021
吴晓昊，首届南方科技大学医学系统学术年会，三等奖， 2021
陈胜，首届南方科技大学医学系统学术年会，优秀奖，2021
郭禺熙, 生物系优秀毕业生, 2020
李茹璇, 校十佳毕业生候选人, 校级优秀毕业生, 2020
李鹏宇, 生物系优秀毕业生, 2020
吴晓昊 南方科技大学生命科学学院首届“学术之星”论坛三等奖，2020
秦雷，教育部博士后基金, 8万，2020
姚青, 深圳市科创委稳定支持，面上项目, 50万，2020
曹惠玲, 国自然面上基金, 55万，2020
曹惠玲, 国自然优秀青年基金获得者, 120万 2020
Yishu Wang, ASBMR Young Investigator Award, Oral Presentation, 2019
王依姝，博士研究生国家奖学金, 2019
Yiming Lei, ASBMR Education Emerging Country Young Investigator Award，2019
Yiming Lei, ICMRS, Third Young Investigator Prize, oral presentation, 2019
Lei Qin, ICMRS, First Young Investigator Prize, oral presentation, 2019
刘鑫, 校十佳毕业生候选人，校级优秀毕业生, 2019
曹惠玲, 深圳市科创委自由探索基金, 50万，2019
高焕庆, 深圳市科创委基金, 40万，2019
Huiling Cao, ICMRS Webster Jee Travel Award, 2018
Xin Liu, ASBMR Travel Award, Plenary Poster, 2017
Xin Liu, ICMRS, First Young Investigator Prize, oral presentation, 2017
Huiling Cao, ICMRS, First Young Investigator Prize, oral presentation, 2017
Huiling Cao, ASBMR, Plenary Poster, 2017
Huiling Cao, ASBMR Travel Award, Plenary Poster, 2016
曹惠玲, 国自然青年基金, 21.16万，2016