个人简介：

博士毕业于香港中文大学，现任南方科技大学基础免疫与微生物学系研究助理教授。近年来已经在Brief in Bioinformatics, Oncogene和Cancer Research等知名期刊发表十余篇学术文章。主要研究兴趣是基于多组学数据研究基因组进化，转录调控机制以及肿瘤代谢。

研究领域： 

1. 基因组进化；
2. 肿瘤代谢；

3. 转录调控机制研究。

工作经历：

2023年 - 至今，南方科技大学基础免疫与微生物学系，研究助理教授

2021 - 2023，南方科技大学系统生物学系，博士后

2020 - 2021，细胞图谱有限公司，首席科学家

2019 - 2020，香港中文大学麻醉及深切治疗学系，博士后

2013 - 2014，香港中文大学深圳研究院，研究助理

学习经历：

2014 - 2018，香港中文大学，化学病理专业，博士

2008 - 2013，哈尔滨医科大学，生物信息专业，学士

代表文章：

1. Pan Y, Chen H, Zhang X, Liu W, Ding Y, Huang D, Zhai J, Wei W, Wen J, Chen D, Zhou Y, Liang C, Wong N, Man K, Cheung AH, Wong CC, Yu J. METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy. Cell Rep Med. 2023 Aug 15;4(8):101144. doi: 10.1016/j.xcrm.2023.101144. PMID: 37586322; PMCID: PMC10439254. 

2. Li Q, Chan H, Liu WX, Liu CA, Zhou Y, Huang D. ... & Yu J. Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice. Cancer Cell. 2023 Jul 14:S1535-6108(23)00236-2. doi: 10.1016/j.ccell.2023.06.011.

3. Bao Y, Zhai J, Chen H, Wong C, Liang C, Ding Y, Huang D. ... & Yu, J.Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer.Gut 2023;72:1497-1509.

4. Chen, H., Pan, Y., Zhou, Q., Liang, C., Wong, C. C., Zhou, Y.,Huang, D. ... & Yu, J. (2022). METTL3 inhibits anti-tumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer. Gastroenterology. 

5. Zhou Z, Hu F, Huang D, Chi Q, Tang NLS. Nonsense-Mediated Decay Targeted RNA (ntRNA): Proposal of a ntRNA-miRNA-lncRNA Triple Regulatory Network Usable as Biomarker of Prognostic Risk in Patients with Kidney Cancer. Genes (Basel). 2022 Sep 15;13(9):1656. doi: 10.3390/genes13091656.

6. Huang, D.*, Wang, X.*., Huang, Z., Liu, Y., Liu, X., Gin, T., ... & Wu, W. K. K. (2022). 3′ untranslated regions of tumor suppressor genes evolved specific features to favor cancer resistance. Oncogene, 1-11.

7. Wang, X., Hu, W., Li, X., Huang, D., Li, Q., Chan, H., Zeng, J., Xie, C., Chen, H., Liu, X. and Gin, T., 2022. Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution. Cancer Research, 82(8), pp.1482-1491. 

8. Wang, X., Cheng, F.T., Lam, T.Y., Liu, Y., Huang, D., Liu, X., Chen, H., Zhang, L., Ali, Y., Wang, M.H. and Yu, J., 2022. Stress Hyperglycemia Is Associated With an Increased Risk of Subsequent Development of Diabetes Among Bacteremic and Nonbacteremic Patients. Diabetes Care. 

9. Liu Y, Ling L, Wong SH, Wang MH, Fitzgerald JR, Zou X, Fang S, Liu X, Wang X, Hu W, Chan H, Wang Y, Huang D, Li Q, Wong WT, Choi G, Zou H, Hui DS, Yu J, Tse G, Gin T, Wu WK, Chan MT, Zhang L. Outcomes of respiratory viral-bacterial co-infection in adult hospitalized patients. EClinicalMedicine. 2021 Jun 10;37:100955. doi: 10.1016/j.eclinm.2021.100955. PMID: 34386745; PMCID: PMC8343259. 

10. Huang, D*., Wang, X*., Liu, Y., Huang, Z., Hu, X., Hu, W., Li, Q., Chan, H., Zou, Y., Ho, I.H. and Wang, Y., 2021. Multi-omic analysis suggests tumor suppressor genes evolved specific promoter features to optimize cancer resistance. Briefings in Bioinformatics, 22(5), p.bbab040.

11. Huang, D., Liu, A.Y., Leung, K.S. and Tang, N.L., 2021. Direct Measurement of B Lymphocyte Gene Expression Biomarkers in Peripheral Blood Transcriptomics Enables Early Prediction of Vaccine Seroconversion. Genes, 12(7), p.971.

12. Ma SL, Wu J, Zhu L, Chan RS, Wang X, Huang D, Tang NL, Woo J. Peripheral Blood T Cell Gene Expression Responses to Exercise and HMB in Sarcopenia. Nutrients. 2021 Jul 5;13(7):2313. doi: 10.3390/nu13072313. PMID: 34371826; PMCID: PMC8308783. 

13. Li, Q., Hu, W., Liu, W.X., Zhao, L.Y., Huang, D., Liu, X.D., Chan, H., Zhang, Y., Zeng, J.D., Coker, O.O. and Kang, W., 2020. Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting β-galactosidase. Gastroenterology .

14. Lee, K.Y., Leung, K.S., Ma, S.L., So, H.C., Huang, D., Tang, N.L.S. and Wong, M.H., 2020. Genome-Wide Search for SNP Interactions in GWAS Data: Algorithm, Feasibility, Replication Using Schizophrenia Datasets. Frontiers in genetics, 11.

15. Ji, L., Wu, D., Xie, H., Yao, B., Chen, Y., Irwin, D.M., Huang, D., Xu, J., Tang, N.L. and Zhang, Y., 2020. Ambient Temperature is A Strong Selective Factor Influencing Human Development and Immunity. Genomics, Proteomics & Bioinformatics .

16. Tang, N.L.S., Hui, J., Huang, D., Tang, M.F., Wang, X., Wu, J., Chan, I.H. and Leung, T.F., 2020. Reference intervals of spot urine copper excretion in preschool children and potential application in pre-symptomatic screening of Wilson disease. Pathology, 52(4), pp.439-446.

17. Tang NL, Wang X, Chang KC, Chan CY, Szeto NW, Huang D, Wu J, Lui GC, Leung CC, Hui M. Genetic susceptibility to Tuberculosis: Interaction between HLA-DQA1 and age of onset. Infection, Genetics and Evolution. 2019 Mar 1;68:98-104 .

18. Wu D, Kang J, Huang Y, Li X, Wang X, Huang D, Wang Y, Li B, Hao D, Gu Q, Tang N. Deciphering global signal features of high-throughput array data from cancers. Molecular BioSystems. 2014;10(6):1549-56.